NEUROJAZ PGM is a triple-therapy formulation designed for the management of neuropathic pain and associated neurological conditions. Pregabalin reduces abnormal neuronal excitability, Nortriptyline enhances pain modulation through monoaminergic pathways, and Methylcobalamin supports neuronal repair and regeneration. Together, these agents offer comprehensive relief from nerve pain, burning sensations, tingling, and numbness while promoting nerve health.
NEUROJAZ PGM is indicated in the treatment of neuropathic pain due to diabetic neuropathy, post-herpetic neuralgia, peripheral neuropathies, cervical or lumbar radiculopathy, and other chronic pain syndromes of neurological origin. It may also be prescribed as part of supportive therapy in conditions involving vitamin B12 deficiency and neurodegenerative changes. Use only under medical supervision.
Pregabalin binds to the α2δ subunit of voltage-gated calcium channels, reducing excitatory neurotransmitter release and thereby decreasing neuropathic pain transmission. Nortriptyline, a tricyclic antidepressant, inhibits reuptake of norepinephrine and serotonin, strengthening descending inhibitory pain pathways. Methylcobalamin, the neurologically active form of vitamin B12, supports myelin sheath integrity and nerve regeneration. The combination provides synergistic benefits for both symptomatic relief and neuroprotection.
Dosage should be individualized as prescribed by the physician. Typically, one capsule/tablet is taken once or twice daily, with or without food, depending on severity and patient tolerance. Dose adjustments may be needed in renal impairment (for pregabalin) or in elderly patients. Do not stop treatment abruptly; tapering is recommended under medical guidance.
Common side effects include dizziness, drowsiness, weight gain, constipation, dry mouth, and blurred vision. Some patients may experience orthostatic hypotension, palpitations, or mild cognitive impairment. Rare but serious risks include mood changes, cardiac arrhythmias (nortriptyline), severe allergic reactions, or suicidal thoughts. Report any severe or persistent adverse effects to your doctor immediately.
Contraindicated in patients with hypersensitivity to any component of the formulation. Use with caution in patients with cardiac disorders, renal impairment, glaucoma, urinary retention, psychiatric illness, or history of substance misuse. Pregnant or breastfeeding women should take only if clearly indicated by a physician.
May interact with CNS depressants such as alcohol, benzodiazepines, or opioids, increasing risk of sedation and respiratory depression. Nortriptyline interacts with MAO inhibitors (contraindicated) and other serotonergic agents (risk of serotonin syndrome). Pregabalin and methylcobalamin generally have low interaction potential, but a full medication review should be done before starting therapy.
Store in a cool, dry place below 25–30°C, away from direct sunlight and moisture. Keep tightly closed and out of children’s reach.
Consult your physician if symptoms worsen, if severe dizziness, palpitations, mood changes, or difficulty breathing occur, or if intolerable side effects are experienced. Do not discontinue abruptly without medical advice.
Q1. What is NEUROJAZ PGM used for?
It is prescribed for neuropathic pain conditions like diabetic neuropathy, post-herpetic neuralgia, and other nerve-related chronic pain syndromes.
Q2. Can I take NEUROJAZ PGM with other painkillers?
Only under medical supervision, as combining with certain analgesics or sedatives may increase side effects.
Q3. Does it cause drowsiness?
Yes, pregabalin and nortriptyline may cause sleepiness or dizziness; avoid driving or operating machinery until you know how it affects you.
Q4. Can I stop taking NEUROJAZ PGM suddenly?
No, it should be tapered gradually under a doctor’s advice to avoid withdrawal symptoms and worsening pain.
Q5. Is it safe for long-term use?
It can be used long-term if monitored by a physician, but periodic check-ups are necessary to adjust dose and assess tolerance.
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